Small sized gadolinium oxide based nanoparticles for high
Zhong et al. reported apolipoprotein E peptide conjugated chimeric polymersomes 40 nm that can mediate a high efficiency GBM therapy . Although smaller particle size can lead to higher BBB permeability of the nanomaterials based on the above mentioned BBB crossing strategies , most of the reported BBB crossable nanomaterials for targeted GBM therapy are larger than 24 nm 4 , 14
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